From my experience and from seeing new members lose their bird needlessly the most import preflight setting is RTH. I live in a hilly area and had an unscientific way of setting my RTH height. Messing around with Google Earth yesterday I found you can set it up to give you elevations not only of the land but of the top of trees. Put the cursor over your starting point to get the elevation and then move your cursor over the highest land area or the top of the highest tree and in the bottome right you will see the elevation you actually need to clear. It is actually fun to play with and I found my RTH point was about 20' lower than it needed to be to clear the highest tree in my area..
Google Earth
Google Earth