@Skywalker : You should search the forums for "FT Aviator"; several users have devised a chair or tripod or monopod to make flying even more relaxed. I have a tripod-mounted platform that secures the FT Aviator beside the RC/mobile device. I admit it's a PITA to set up, but it makes for a very pleasant flying experience.
I should note that I got the FT Aviator because my hands are rather shaky (essential tremor). That big joystick is a
lot easier for me to use than the little thumb-sticks on the native remote controller. Recent updates improved the in-air handling, making the FT Aviator is by far my favorite way to fly. For me--using a conventional two-stick remote--it's very difficult to make a smooth curving flight with a slow pan and/or elevation change. I know some people find two-sticks" natural, but not me. Maybe I just have dumb thumbs.
That said, the FT Aviator consolidates all aircraft flight controls in the joystick hand, and all other controls in the base. A truly one-handed pilot would have to release the joystick (i.e., go to a stationary hover) to change the gimbal angle. In short, a single-handed pilot can't tilt the gimbal as the drone simultaneously moves in some direction. However, even minimal use of "the other hand" may suffice; the gimbal control is just a variable-speed rocker-switch that doesn't demand high dexterity. The other base controls (the 5-position "joystick sensitivity" knob, exposure control, launch, RTH, and so on) are generally not changed during a take.
Note that the FT Aviator is only compatible with the DJI drones listed for it. They say they have plans to support additional drones in the future, but I wouldn't hold my breath. Even if other manufacturers have an SDK, I would bet that porting the control app to a whole new platform would not be trivial. DJI is the big dog in the drone market, and the FT Aviator has to make a pot o' money before they can afford a big investment that doesn't promise anything near the potential sales volume present in the DJI ecosystem.