At some point maybe, but it would likely only be inside a building, or in the depths of a deep gorge etc, where some overhead sats may be 'visible' to the drones receiver, and more lateral ones might be blocked.
But even inside my home, when checking for updates or playing with settings etc, I usually get good satellite reception and home point recorded.
Outside I have never had a problem getting a sat lock almost before I'm ready to fire up the motors, and never lost GPS once locked in, and you probably won't have any issues either.
VLOS is important for staying within CASA rules of course, but to be clear, it's more LOS that will be a possible problem with failsafe RTH being activated, it won't affect GPS function and that side of things.
LOS is similar to VLOS, except of almost all DJI consumer drones LOS is far far further than VLOS.
LOS is related to signal from controller to drone more so.
If nothing between you and the drone, you are facing the drone with antenna orientated properly, you should have great signal and control reliability way out past VLOS, so flying to CASA regs you will never have a problem.
Also staying that close (with strobes maybe up to 1km or so in some places) you avoid interference like trees / foliage, hilly terrain if flying lower down, and if flying behind something briefly you will be less likely to lose that signal for a short period