Yes, a collision between a drone and an airliner could bring a 737 down, especially during takeoff or landing when aircraft are most vulnerable.
By the way, when a light twin loses one engine it loses 80% of its performance, not 50%. If the pilot does not stay on VMC, VYSE and zero slip, game over.
and @Blades you keep talking about toys a 2 onz drone ,but never mention drones like an inspire 2 flown by a novice. That one could take down any plane.or kill a person playing in a park. so as much as we hate regulations, these are necessary to live as a society.